摘要
目的研究胃肠道肿瘤患者的促红细胞生成素受体(Epo-R)表达及其与肿瘤血管生成的关系。方法应用免疫组化方法检测43例胃癌和38例结直肠癌患者的Epo-R的表达,同时检测肿瘤微血管密度(MVD),并分析与临床病理之间的关系。结果①81例MVD平均计数为(29.62±9.61)个,70例表达Epo-R(平均阳性率为39.98±25.01%);②MVD与Epo-R呈正相关(r=0.3514、t=3.3340、P<0.001);Epo-R阳性表达患者的MVD明显高于Epo-R阴性患者(t=2.9565、P<0.01);③MVD和Epo-R均与有无转移、分期、分化程度和肿块大小均无关(均为P>0.05)。结论胃癌和结直肠癌患者高表达Epo-R,并与MVD呈正相关关系。MVD和Epo-R均与临床病理特征之间无明确关系。
Objective To study erythropoietin receptor（Epo - R） expression in gastric cancer and colorectal cancer and its relationship with neovascularization. Methords The expression of Epo - R and microvascular ensity（MVD） was detected by immunohistochemistry for 81 patients with gastric cancer and colorectal cancer. Results ①The rate of MVD and Epo - R were （29.62 ± 9.61 ） % and （39.98 ± 25.01 ） % respectively ; ②The expression of Epo - R was positively correlation with the MVD （ r = 0. 3514, t = 3. 3340, P 〈 0. 001 ） ; MVD increased with the increase of Epo - R expression. ③The MVD and Epo - R were no significantly correlated with the metastasis,size, clinical staging and histological grade. Conclusion The expression of Epo - R in gastric cancer and colorectal cancer was correlation with MVD,but there was no significantly correlated with the metastasis,size, clinical staging and histological grade.
出处
《医学研究杂志》
2009年第7期70-72,共3页
Journal of Medical Research
