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39例胃肠道间质瘤的病理诊断与临床分析 被引量:1

Clinical and Pathological Features of Gastrointestinal Stromal Tumor(GIST):a 39 Cases Report
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摘要 目的探讨胃肠道间质瘤(GIST)的临床病理、免疫组化特点及危险度参考指标,分析其在临床预后评估中的价值。方法观察39例GIST的病理形态特征,完成肿瘤性质初步判定,采用免疫组化方法检测分析CD117、CD34、SMA及S-100的表达水平,最终确定GIST的临床病理诊断性质、特征、组织来源以及良恶性。结果免疫组化染色显示CD117呈弥漫强阳性,CD34多呈弥漫强阳性,SMA及S-100偶呈局灶或散在阳性,阳性率分别为100%、81%、20%和16%。确诊该组39例GIST,其中可能良性5例,潜在恶性10例,恶性24例。结论免疫组化测定是GIST病理诊断的重要依据,CD117是诊断GIST的敏感而特异性的标志物。肿瘤病理判定与患者预后密切相关。 Objective To explore the criteria of pathologic diagnosis for gastrointestinal stromal tumors (GIST)and the reference parameters for malignancy,and to evaluate the clinical prognosis. Methods The expression levels of CD117,CD34,SMA and S-100 were detected by immunohistochemical method and their morphologic characteristics were analyzed by Light microscopy. Results The immunohistochemical results showed that CDl17 were diffusely strongly expressed in all of GIST;CD34 also diffusely strongly in most of GIST;SMA and S-100 incidentally in some focus. Their positive rates were 100 %, 81 %, 20% and 16 % respectively. 5 benign cases, 10 potential malignancy cases and 24 malignant cases were finally diagnosed. Conclusion The pathologic diagnosis of GIST should he made based on the immunohistochemical staining results. CD117 was a sensitive and specific marker for diagnosing GIST. The prognosis was closely related to the degree of pathologic malignancy.
出处 《中西医结合研究》 2009年第3期140-142,共3页 Research of Integrated Traditional Chinese and Western Medicine
关键词 胃肠道 间质瘤 抗原CD117 CD34 Gastrointestinal tract Stromal tumor CDll 7 CD34
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参考文献9

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同被引文献26

  • 1Makoto Iwahashi MD,Katsunari Takifuji MD,Toshiyasu Ojima MD,Masaki Nakamura MD,Mikihito Nakamori MD,Yoshihiro Nakatani MD,Kentaro Ueda MD,Koichiro Ishida MD,Teiji Naka MD,Kazuo Ono MD,Hiroki Yamaue MD.Surgical Management of Small Gastrointestinal Stromal Tumors of the Stomach[J]. World Journal of Surgery . 2006 (1)
  • 2Bryan M. Clary MD,Ronald P. DeMatteo MD,Jonathan J. Lewis MD,Denis Leung PhD,Murray F. Brennan MD.Gastrointestinal Stromal Tumors and Leiomyosarcoma of the Abdomen and Retroperitoneum: A Clinical Comparison[J]. Annals of Surgical Oncology . 2001 (4)
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