口服尼莫地平对脑卒中后血管性认知功能障碍的预防作用

The observation of the curative effect of Nimodipine to vascular cognitive impairment post stroke

目的探讨尼莫地平防治脑卒中后血管性认知功能障碍(VCI)的临床疗效。方法将132例脑卒中患者随机分为:预防治疗组63例与对照组69例,对两组原发病均遵照神经内科诊疗指南进行常规治疗,治疗组另予尼莫地平片30mg,每日3次,口服;常规治疗疗程均为2～4周,预防治疗组持续给予尼莫地平6个月。进行智能测定,以观察两组治疗后血管性认知功能障碍的改善情况。应用修订简易精神状态量表(MMSE)评价疗效。结果与对照组比较预防治疗组可显著提高MMSE评分,差异有统计学意义(P<0.05)。结论对脑卒中患者早期给予口服尼莫地平干预治疗防止VCI的发生发展疗效确切。

Objective To investigate the curative ettect of Nimodipine to vascular cognitive impairment （VCI） post stroke. Methods One hundred thirty three （132） stroke patients were enrolled. All the enrolled patients were randomly chosen and divided into a prevention group and a control group, ~ith 63 cases in the prevention group and 69 cases in the control group. In each group the incidence of the original were routinely treated with guidelines of neurology. The course of treatment ran for 2-4 weeks. The prevention group took Nimodipine tablet orally 30mg ever eight hours. And the duration of administration was 6 months. MMSE used to estimate the therapeutic effect. Resealts Compared with the control group, the prevention group increased the MMSE scores significantly （P〈 0.05）. Conclusion Early intervention treatment by taking Nimodipine tablet orally is effective for VCI post stroke.