乙型肝炎肝硬化合并肝源性糖尿病53例临床分析

Clinical Analysis of 53 Cases with HBV-related Hepatocirrhosis Concomitant with Hepatogenic Diabetes

目的探讨乙型肝炎肝硬化与肝源性糖尿病的关系和临床特点。方法对乙型肝炎肝硬化合并肝源性糖尿病53例临床资料进行回顾性分析,并与同期住院的45例无肝源性糖尿病的乙型肝炎肝硬化病例进行对照。结果肝硬化并发肝源性糖尿病的主要临床表现为肝病的症状,较少出现糖尿病的"三多一少"症状,肝源性糖尿病的轻重与肝硬化的严重程度成正相关,肝性脑病、各种感染等并发症的发生率与对照组比较,差异有统计学意义(P<0.05或P<0.01)。结论肝源性糖尿病也是乙型肝炎肝硬化常见的并发症,应予以积极的护肝、控制血糖和肝硬化等并发症的治疗。

Objective To explore the relationship, the clinical feature diagnosis, and the therapy between HBV-related cirrhosis and hepatogenic diabetes. Methods Retrospective analysis of clinical data in 53 cases witb HBV-related hepatocirrhosis concomitant with hep- atogenie diabetes, in comparison with 45 cases in hospital with HBV-related cirrhosis without hepatogenic diabetes in the same tenn. Resealts The main clinical manifestations of hepatocirrhosis with hepatogenic diabetes are hepatopathy symptoms, while the characteristic of diabetes ＂ Three being the most and one being the least,＂ i.e. polydipsia, polyphagia, polyuria and weight loss were seldom found. The severity of hepatogenie diabetes had a positive correlation with hepatocirrhosis progression, compared with the ratio of hepatic encephalopathy, various infections, and other complications in the control group. Significant differences were observed between the two groups （P〈0.05 or P〈0.01）. Conclusion hepatogenic diabetes is also a common complication originated from HBV-related cirrhosis, which needs active liver-protecting therapy, good control of blood glucose, and treatment of the hepatocirrhosis complications.