CEA、CYFRA21-1、TSGF联合同步检测在恶性胸水诊断中的应用

CEA, CYFRA21-1, TSGF Joint Simultaneous Detection for the Diagnosis of Malignant Pleural Effusion

目的通过对血清及胸水中CEA(癌胚抗原)、CYFRA21-1(细胞角蛋白19片段)、TSGF(恶性肿瘤特异性生长因子)的检测,探讨此三项指标在恶性胸水诊断中的应用。方法应用酶联免疫法(ELISA)对59例恶性胸水和48例良性胸水进行联合同步检测。结果恶性胸水组中血清及胸水的CEA、CYFRA21-1、TSGF明显高于良性胸水组(P<0.01)。三项联合检测血清敏感性为84.75%,特异性为68.75%;胸水敏感性为93.22%,特异性为60.42%。结论CEA、CYFRA21-1、TSGF对血清与胸水的联合同步检测在恶性胸水的诊断中有重要价值。

Objective Investigate the relationship between serum and pleural fluid CEA （carcinoembryonic antigen）, CYFRA21-1 （cytokeratin 19 fragment）, TSGF （tumor specific growth factor） in the diagnosis of malignant pleural applications. Methods Application of enzyme-linked immunosorbent assay （ELISA） of 59 cases of malignant pleural effusion and 48 patients with benign joint synchronous detection.Results Malignant pleural effusion group and the serum CEA, CYFRA21-1, TSGF effusion was significantly higher than benign group （P 〈0.01）. Combined detection of three serum sensitivity of 84.75% and specificity of 68.75%; Hydrothorax sensitivity of 93.22% and specificity of 60.42%. Conclusions CEA, CYFRA21-1, rpSGF serum and pleural effusion of joint synchronization detection in the diagnosis of malignant pleural effusion has important value.