地衣芽胞杆菌活菌制剂联合庆大霉素预防伊立替康所致腹泻

Bacillus licheniformis granules combined with Gentamycin for prevention of irinotecan-induced diarrhea

目的观察地衣芽胞杆菌活菌制剂(整肠生胶囊)联合庆大霉素预防伊立替康(irinotecan,CPT-11)所致腹泻的疗效。方法31例接受含伊立替康方案化疗的晚期癌症患者,采用自身随机交叉对照的方法,分别于2个治疗周期接受化疗(对照组)、化疗+整肠生胶囊+庆大霉素(预防组),比较腹泻及其他不良反应的差异。结果31例患者在2个治疗周期中,预防组较对照组腹泻发生率有显著降低(腹泻发生率分别为48.4%vs 61.3%,P<0.05;3/4级腹泻发生率分别为9.7%vs 16.1%,P<0.05),且减少合并用药;同时骨髓抑制、食欲减退、恶心呕吐的发生率也有所降低(P<0.05),而2组便秘、肝肾功能异常差异无显著性。结论地衣芽胞杆菌活菌制剂联合庆大霉素能有效预防伊立替康所致腹泻。

Objective To assess the preventive effect of Bacillus licheniformis granules combined with Gentamycin on irinoteean-indueed diarrhea. Method 31 cancer patients received chemotherapy including irinotecan were d/vided into test group （ Chemotherapy ＋ Bacillus licheniformis granules ＋ Gentamycin） and control group （ chemotherapy only） with cross-over self-controlled randomized method. All adverse effects were evaluated using NCI-CTC standard. Result Prophalyxis of chemotherapy-induced diarrea by Bacillus licheniformis granules and Gentamycin was effctive （diarrea 61. 3% in control group, 48.4% in test group） , and reduced grades of diarrea （ heavy diarrea 16.1% in control group, 9.7 in test group）, significantly different （ P 〈 0.05 ）, indicating that Prophalyxis of chemotherapy-induced diarrea by Bacillus licheniformis granules and Gentamycin was confirmed. Conclusion Bacillus licheniformis granules combined with Gentamycin can reduce the incidence and grade of Irinotecan-induced Diarrhea.