广州地区74株淋球菌耐药性结果分析

Analysis of antibiotic resistance of Neisseria gonorrhoeae in Guangzhou

目的了解广州地区淋球菌对抗生素的耐药性及PPNG和TRNG的流行状况。方法用琼脂稀释法测定最低抑菌浓度(MIC);用纸片碘量法检测β-内酰胺酶。结果74株淋球菌检出PPNG 31株(41.9%)、TRNG 19株(25.7%)、环丙沙星耐药率达97.3%,高度耐药株(MIC≥16 mg/L)22株(29.7%),未发现对头孢三嗪、壮观霉素耐药的菌株,且抗菌活性最强。结论持续监测淋球菌的耐药性十分重要。

Objective To explore the antibiotic resistance and the prevalence of PPNG and TRNG in Guangzhou. Method Minimum inhibitory concentrations （MIC） to penicillin G, tetracycline, ciprofloxacin, ceftriaxone and spectiomycin were determined using the agar dilution method, and β-1actamase by paper iodin quantitative method. Result Of the total 74 strains of Neisseria gonorrhoeae produced β-lactamase, while 19 strains showed plasmid-mediated, high-level resistance to tetracycline（TRNG）. The resistant rates to ciprofloxacin was as much as 97.3% ;22 strains were highly resistant （ MIC 〉 = 16 rag/L）. No strains were found to be resistant to ceftriaxone and specitinomycin. Conclusion The study showed that it is important to successively monitor the antibiotic resistance, of Neisseriae gonorrhoeae.