吉西他滨联合顺铂治疗晚期膀胱癌54例疗效分析

Analysis of 54 cases of advanced bladder cancers treated with gemcitabine plus cisplatin

目的探讨晚期膀胱癌的有效而安全的化疗方案。方法对54例晚期膀胱癌应用吉西他滨联合顺铂(GC)方案化疗,第三周重复,共治疗6个周期。结果54例患者完全缓解(CR)9例,部分缓解(PR)21例,总有效率为55.6%,中位生存期为15.1个月。毒性反应主要为白细胞下降、贫血等,均为轻中度,没有因治疗引起死亡。结论GC方案治疗晚期膀胱癌患者疗效肯定,毒副作用较轻,可作为一线治疗方案。

Objective To analyse the efficacy and toxicity of gemcitabine plus cisplatin in the treatment of patients with advanced bladder cancers. Methods Fifty-four cases of advanced bladder cancers were treated with gemcitabine plus cisplatin（ GC）, the regimen was repeated every 21 days. All patients received six cycles of the treatment. Resluts All patients were included in the efficacy and adverse events a- nalysis. There were 9 complete response, 21partial response, with an overall response rate of 55.6% （30/ 54）. The median survival time were 15.1 months. The major toxicity was myelotoxicity, with grade I / Ⅱ myelosuppression. Conclusion GC is an effective and acceptable regimen for advanced bladder cancers, and may be one of the most effective therapy for advanced bladder cancers.