奥施康定治疗晚期癌痛82例

Efficacy of oxycontin in the treatment of advanced tumor pain

目的观察奥施康定治疗晚期癌痛的疗效及其毒副反应。方法门诊及病房共同收治晚期肿瘤患者82例,按照镇痛三阶梯原则给予不同剂量奥施康定口服,观察近期疗效及毒副反应。结果82例患者中72例有效,最小日服量为40 mg,最大日服量为720 mg,总有效率为87.8%。7例恶心,28例出现腹胀伴便秘,3例头晕,2例嗜睡,3例出现皮疹,3例口干。结论奥施康定可作为晚期肿瘤中至重度疼痛患者的首选口服药物之一。

Objective To observe the efficacy and toxicity of oxycontin in the treatment of 82 advanced tumor patients. Methods Different doses of oral oxycontin were given to outpatients and inpatients with advanced tumors in accordance with the principles of the three analgesic ladder, and their short term efficacy and toxicity were observed. Results Seventy-two of the 82 patients were effective after taking oxycontin, with minimal daily dose of 40 mg and maximal daily dose of 720 mg. The total effective rate of oxycontin was 87.8%. The toxicity was as follows： nausea in 7 cases, abdominal distension with constipation in 28 patients, dizziness in 3 cases, somnolence in 2 cases, skin rashes in 3 cases, mouth dryness in 3 cases. Conclusion Oxycontin can be taken as one of the first preferred oral drugs for treatment of advanced tumor patients with severe pain.