CuI在烯丙基格氏试剂与醛酮加成反应中的应用研究

The Application of CuI to the Addition of Allylic Grignard Reagent With Carbonyl Compounds

为有效抑制烯丙基格氏试剂与醛酮加成反应中的重排反应，进行了ＣｕＩ对此类格氏试剂及加成产物组份比例关系的研究，得出了ＣｕＩ对这类化合物加成反应重排有明显的抑制作用的结论，ＣｕＩ的最佳用量组份比例为２５％．根据实验结果提出了在ＣｕＩ存在条件下烯丙基格氏试剂与醛酮化合物加成反应的反应机理．

The reaction of allylic Grignard reagent with carbonyl compounds may make a mixture of alchols comprising rearranging and nonrearranging products, and the former is main. Copper(Ⅰ) iodide has a apparent effect on both the Grignard reagent and its additional products. The ratio of products prepared from carbonyl compounds to each other and the amount of copper(Ⅰ) iodide used are studied. On the other hand, a new reactive mechanism is proposed to the addition of allylic Grignard reagent with carbonyl compounds in the presence of copper(Ⅰ) iodide.