聚维酮K30、S630对尼美舒利分散片分散性能的影响

Comparison of Dispersibility Between Plasdone K30 and Plasdone S630 in Nimesulide Dispersible Tablets

目的:比较2种聚维酮类亲水性黏合剂对尼美舒利分散片分散性能的影响。方法:分别选择聚维酮S630和K30的5%乙醇溶液及5%水溶液作为亲水性黏合剂制备尼美舒利分散片,通过检测各组分散片的脆碎度、硬度和分散性比较二者对分散片性能的影响。结果:从分散片的脆碎度、硬度和分散性等方面考察,聚维酮S630的乙醇溶液或水溶液与K30的乙醇溶液或水溶液比较性能相同甚至在分散性方面前者更好。结论:聚维酮S630可以作为K30的替代物用作分散片的亲水性黏合剂。

OBJECTIVE： To compare dispersibility between two kinds of plasdone used as the hydrophilic adhesive in nimesulide dispersible tablets. METHODS： Nimesulide dispersible tablets were prepared with Plasdone S630 and Plasdone K30 as the hydrophilic adhesive respectively which were dissolved in 5% alcohol solution or 5% water solution. By friability, hardness and dispersibility tests, the influence of S630 and K30 in quality of nimesulide dispersible tablets were observed. RESULTS： Plasdone S630 alcohol solution or aqueous solution showed same or better results in friability, hardness and dispersibility compared with Plasdone K30 alcohol solution or aqueous solution. CONCLUSION： Plasdone S630 could be used as a alternate of K30 for hydrophilic adhesive in dispersible tablets.