摘要
胰腺癌是恶性程度最高的肿瘤之一,具有起病隐匿,手术治疗切除率低,传统放化疗不敏感的特点,预后极差.经研究证实辅助化疗比最佳支持治疗延长了晚期胰腺癌的生存时间.吉西他滨是胰腺癌辅助化疗的标准治疗,疗效较传统化疗有所提高.随着研究的深入,出现了多种针对胰腺癌的靶向药物(包括细胞毒药物或生物靶向药物),给胰腺癌的辅助化疗带来希望.
Pancreatic carcinoma is one of the most malignant tumors with characteristics of insidious onset, and low surgical curative rate, insensitivity to traditional chemoradiotherapy and poor prognosis. It is found that the adjuvant chemotherapy had held an edge over supporting therapy and the survival was extended. As a representative drug for adjuvant chemotherapy, gemcitabine shows favorable efficacy in comparison with traditional chemotherapy. With some further researches undergoing, a variety of targeted drugs （include cytotoxic drugs or bio-targeted drugs） have brought a new prospect for the adjuvant chemotherapy of pancreatic carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第14期1422-1426,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30772541
江苏省"科教兴卫工程"医学重点人才基金资助项目
No.109~~
关键词
胰腺癌
辅助化疗
靶向药物
Pancreatic carcinoma
Adjuvant chemotherapy
Targeted drugs
