高原缺氧与肠黏膜屏障损伤研究进展

Research advances in plateau hypoxia and gut barrier injury

肠屏障功能是肠道的一个重要特征,他由机械屏障、免疫屏障、化学屏障和生物屏障组成,各个屏障具有不同的结构、分子调控机制和生物学机能,同时又通过各自的信号通路有机结合在一起,从而保护宿主不受外来抗原的干扰和入侵.高原环境下对这些屏障的损伤是一个复杂的,且相互关联的过程,伴随着体内多种炎症介质的改变和病理过程.本文就这一特殊自然环境下对肠黏膜损伤的机制作一综述.

Gut barrier function is an important feature of the intestinal tract. It consists of mechanical barrier, immune barrier, chemical barrier and organism barrier. Each barrier has different structures, molecular regulatory mechanisms and biologic functions, which are connected organically via their own signal paths simultaneously to protect the host from intruding of foreign antigen. The injury to these barriers in the plateau environment is a complex and inter-related process with many changes of inflammatory mediators and pathologic procedure. In this review, we focus on the barrier injury mechanisms under this special environment.