黄马酒长期毒性试验研究

Study of Long-Term Toxicity Test of Mahuang Wine

目的观察黄马酒长期连续经皮肤给药对大鼠的毒性反应,为临床用药提供依据。方法采用高、低剂量黄马酒,分别经大鼠完整皮肤及破损皮肤每天给药1次,连续30d,观察大鼠一般性状,检测主要血液学指标、血液生化指标及主要脏器病理组织学的变化。结果黄马酒高、低剂量组主要血液生化学指标、主要脏器系数等均在正常范围内,与空白对照组无统计学差异,解剖主要脏器未见病理性改变。结论黄马酒长期连续经皮肤给药,试验大鼠未出现毒性反应,在临床剂量下使用安全。

Objective To observe the long- term toxicity of Mahuang Wine on the rat skins with successive administration for providing the evidence of its clinical application. Methods We had applied high and low doses of Mahuang Wine once daily on healthy and punctured the rat skins respectively for continuous 30 d. The rats＇ general properties were observed, and the hematological and biochemical indexes and histopathotogical changes of major organs were also detected. Results The rat main hematological and biochemical indexes had no change, the results of all detections were normal. There was no significant difference between the test group and control group. The rat major organs had no change in anatomy and pathology. Conclusion No long- term toxic reaction can be found in the test applied Mahuang Wine on the rat skins for a long time. It is safe using the normal dose of this wine on the skin in clinic.