颗粒硫酸钙应用于腰椎后外侧融合29例3年随访

Application of calcium sulfate pellets in lumbar spine posterolateral fusion in 29 patients: A three-year follow-up

卫生部北京医院骨科于2005-01/12对29例患有腰椎管狭窄和腰椎滑脱患者进行1或2节段椎管减压椎弓根钉内固定后外侧融合,植骨双侧采用相同体积的植骨材料(半水硫酸钙颗粒及等量自体减压骨混合)。29例患者随访2.5～3.5年,平均3.1年。术后6个月颗粒硫酸钙完全吸收;12例单节段融合的患者中,7例完全融合,3例疑似融合,未融合2例;17例2节段融合的患者中,8例完全融合,4例疑似融合,5例未融合。术前改良ODI评分82.40±4.82,术后3年为9.20±1.56,改善率88.3%。说明在腰椎后外侧短节段融合中,作为一种植骨扩充剂颗粒硫酸钙吸收较快,半年内完全降解,具有一定的融合效果。

A total of 29 patients diagnosed degenerative lumbar spine stenosis or spondylolisthesis underwent decompression and one- or two-segment posterolateral spine fusion with pedicle screws fixation at the Department of Orthopaedics, Beijing Hospital of Ministry of Public Health from January to December 2005. Equal quantities of autogenous laminectomy bone supplemented with calcium sulfate were placed in both posterolateral gutters. 29 patients were followed-up ranged from 2.5 to 3.5 years, averaging 3.1 years. Calcium sulfate was completely absorbed 6 months following surgery. For the 12 patients who received single-segment fusion, 7 patients exhibited bone fusion on both sides and 3 patients were diagnosed having doubtful fusion, as well as 2 patients were not fused. For the 17 patients who received two-segment fusion, 8 patients exhibited bone fusion on both sides and 4 patients were diagnosed doubtful fusion, and 5 patients were not fused. Score of Oswestry Disability Index （ODI） was （82.40±4.82） points prior to surgery, but （9.20±1.56） points 3 years following surgery, resulting in an improvement rate of 88.3% This indicated that as a bone graft extender in short-segment spinal fusion, the absorption of calcium sulfate pellets was comparatively faster, and completely degraded in half a year, with a high total fusion rate.