C-反应蛋白在脑血管狭窄病人中的相关研究

The Study on C-Reactive Protein Level in the Patients with Stenosis of Cerebral Arteries

目的:探讨脑血管狭窄病人血清中C-反应蛋白(C-reactivc protein,CRP)水平及其与胆固醇、尿酸的相关关系。方法:采用散射免疫比浊法分别测定本院神经内科脑血管狭窄住院病人106名通过脑血管造影术诊断的脑血管狭窄患者和42名通过颅脑血管颅脑多普勒检查的正常健康体检者血清中CRP的水平并进行相互比较。结果:脑血管狭窄组血清CRP水平明显高于对照组(狭窄<70%组:16.22±10.45vs4.21±3.01 mg/L狭窄>70%组:21.36±11.45vs4.21±3.01 mg/L,P<0.01),具有统计学意义。Logistic回归分析显示CRP和脑血管狭窄(>70%)有相关关系,有统计学意义。结论:CRP水平的升高,对严重脑血管狭窄患者病情的预测及观察有一定的价值。

Objective： To investigate the level of C-Reactive Protein （CRP） in the sera of patients with stenosis of cerebral arteries and the correlation between stenosis of cerebral arteries and cholesterol or uric acid. Methods： CRP levels were measured by scattering immunoturbidimetry in the sera of 106 patients with stenosis of the cerebral arteries established by angiography and compared with those in the control group on ultrasound examination. Results：CRP level in the group of patients with cerebrovascular stenosis were significantly different from those in the control group （ group of less than 70% ：16.22 ± 10.45 vs 4.21 ± 3.01mg/L. group of more than 70% ：21.36 ± 11.45 vs 421 ± 3.01 mg/L, P 〈 0. 05 ）. At logistic regression analysis, CRP was significantly associated with stenosis of more than 70%. Conclusion： An elevated CRP level may be useful in the prognostication and detection of patients with severe stenosis of the cerebral arteries.