多西他赛联合顺铂时辰化疗治疗晚期非小细胞肺癌的临床研究

Clinical research of chrono-chemotherapy with docetaxel pius cisplatin for advanced non-small cell lung cancer

目的比较多西他赛联合顺铂的时辰化疗与常规化疗治疗晚期非小细胞肺癌(NSCLC)的疗效和不良反应。方法70例晚期非小细胞肺癌患者随机分为两组,实验组36例予时辰化疗,多西他赛75mg/m2静脉滴注第1天,4:00AM开始,静脉滴注3h,顺铂75mg/m2静脉滴注第1天,10∶00AM开始,至22∶00PM结束;对照组34例予常规化疗,每天10∶00AM给予多西他赛联合顺铂(两药剂量同时辰化疗组),化疗至少两周期后评价近期疗效。结果时辰化疗组有效率(CR+PR)为58%(21/36),常规化疗组有效率为(CR+PR)为34%(13/34),两组有效率比较,差异有统计学意义(P<0.05),主要不良反应为血液学毒性及消化道毒性,时辰化疗组较常规化疗组低(P<0.05),两组疾病进展时间(TTP)及生存期比较,差异均无统计学意义(P>0.05)。结果多西他赛联合顺铂时辰化疗治疗晚期非小细胞肺癌疗效高于常规化疗,不良反应明显小于常规化疗,值得临床进一步研究。

Objective To compare the efficacy and toxicity of chrono-chemotherapy（ docetaxel and cisplatin）with routine-chemotherapy for advanced non-small cell lung cancer. Methods 70 cases of NSCLC patients were randomly grouped,36 cases for chrono-chemotherapy were treated with docetaxel 75mg/m^2. from 4：00AM to 7： AM, cisplatin 75mg/m^2, from 10 ： 00AM to 22 ： 00PM ; and 34 cases were treated with conventional chemotherapy preoceeded on 10：00AM, For needs of evaluation, all patients must complete at least two cycles. Results The totle response rate（CR＋PR） in chrono-chemotherapy and conventional chemotherapy were 58% and 34% respectively, The difference between two groups had statistical significance, The main adverse events of chemotherapy were leucopenia, gastro intestinal discomfort, and the toxicity of chrono-chemotherapy groups were lowed to routine-chemotherapy groups, The difference between two groups had statistical significance, No difference were found between two groups in time to progress （TTP） and survival time. Conclusion The chrono-chemotherapy （docetaxel and eisplatin） was more effective than routine-chemotherapy for advanced non-small cell lung cancer, and had lower adverse reactions as well. More clinical research should be taken.