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IGF-1R在胰腺癌中的表达及其临床意义 被引量：3

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摘要 目的探讨胰腺癌组织中IGF-1R的表达及其临床意义。方法应用原位杂交(DNA-RNA)技术与免疫组织化学SP法检测34例胰腺癌组织和10例正常胰腺组织中IGF-1R mRNA和IGF-1R蛋白的表达,并分析其与临床病理、预后的关系。结果IGF-1R mRNA和IGF-1R蛋白在胰腺癌组织中阳性表达率分别为58.82%和55.88%,在正常胰腺组织中阳性表达率分别为20.00%和10.00%。两者差异均有显著性(P<0.05;P<0.01)。在胰腺癌组织中,有淋巴结转移组IGF-1R阳性表达明显强于无淋巴结转移组(P<0.05);病理Ⅲ、Ⅳ期组的IGF-1R阳性表达明显强于Ⅰ,Ⅱ期组(P<0.05)。IGF-1R表达阳性组的生存时间较阴性组明显缩短(P<0.05)。结论IGF-1R胰腺癌组织中表达增强且与胰腺癌淋巴结转移及预后有关。
作者 肖君 孙维佳 张翼 黄之果 文言广
机构地区 湖南省岳阳市一医院胸心甲乳外科 中南大学湘雅医院普通外科 中南大学湘雅三医院普通外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2009年第6期639-642,共4页 China Journal of General Surgery
关键词 胰腺肿瘤/病理学 腺癌 IGF-1R 预后
分类号 R735.9 [医药卫生—肿瘤]
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参考文献5

  • 1Hakam A, Yeatman TJ, Lu L, et al. Expression of insulin- like growth factor-1 receptor in human colorecta cancer [ J]. Hum Pathol, 1999,30(10) :1128 -1133.
  • 2Samani AA, Brodt P. The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis [ J ]. Surg Oncol Clin N Am, 2001 ,10(2) :289 -312.
  • 3Tang Y, Zhang D, Fallavollita L, et al. Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor [ J ]. Cancer Res,2003,63(6) :1166-1171.
  • 4Long L, Rubin R, Baserga R, et al. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor [ J ]. Cancer Res, 1995,55 (6) : 1006 - 1009.
  • 5牛坚,李向农,韩泽广.靶向IGFIR的siRNA抑制人肝癌裸鼠移植瘤的实验研究[J].中国普通外科杂志,2007,16(8):774-777. 被引量：3

二级参考文献8

  • 1牛坚,钱海鑫,李向农,黄健,韩泽广.RNA干涉胰岛素样生长因子1类受体的研究[J].中华实验外科杂志,2006,23(7):872-872. 被引量：19
  • 2Russell WE,Van Wyk JJ,Pledger WJ,et al.Inhibition of the mitogenic effect of plasma by amonoclonal antibody to somatomedin C[J].Proc Natl Acad Sci USA,1984,81 (8):2389 -2393.
  • 3Valentinis B,Baserga R.IGFI receptor signalling in transformation and differentiation[J].Mol Pathol,2001,54(3):133 -137.
  • 4Hellawell GO,Turner GD,Davies DR,et al.Expression of the type insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease[J].Cancer Res,2002,62 (10):2942 -2950.
  • 5Weidner N.Intratumor microvessel density as prognostic factor in cancer[J].Am J Pathol,1995,147(1):9-13.
  • 6Valentinis B,Baserga R.IGF1 receptor signalling in transformation and differentiation[J].Mol Pathol,2001,54(3):133 -137.
  • 7Hellawell GO,Turner GD,Davies DR,et al.Expression of the type insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease[J].Cancer Res,2002,62(10):2942 -2950.
  • 8Resnicoff M,Burgaud JL,Rotman HL,et al.Correlation between apoptosis,tumorigeneisis,and levels of insulin like growth factor 1 receptors[J].Cancer Res,1995,55(17):3739-3741.

共引文献2

同被引文献47

  • 1郭明华,徐红.IGF-1及IGFBP-3的结构功能及其与子宫内膜癌关系的研究进展[J].广西医科大学学报,2009,26(6):989-991. 被引量：3
  • 2Kim JH, Cho YH, Park YL, et al. Prognostic significance of insulin growth factor-I receptor and insulin growth factor binding protein-3 expression in primary breast cancer [ J ]. Oncol Rep,2010,23 (4) :989 -995.
  • 3Sichani MM, Yazdi FS, Moghaddam NA, et al. Prognostic value of insulin-like growth factor-I receptor expression in renal cell carcinoma [ J]. Saudi J Kidney Dis Transpl, 2010, 21(1):69-74.
  • 4An Y, Cai L, Wang Y, et al. Local expression of insulin- like growth factor-I, insulin-like growth factor-I receptor, and estrogen receptor alpha in ovarian cancer [ J ]. Onkologie, 2009,32(11) :638 -644.
  • 5Gualco E, Wang JY, Del Valle L, et al. IGF-IR in neuroprotection and brain tumors [ J ]. Front Biosci, 2009, 1 (14) :352 -375.
  • 6Yavari K, Taghikhani M, Ghannadi Maragheh M, et al. Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells[ J] . Int J Colorectal Dis, 2010, 25 ( 1 ) :9 - 16.
  • 7Yavari K, Taghikhani M, Maragheh MG, et al. Knockdown of IGF-IR by RNAi inhibits SW480 colon cancer cells growth in vitro[J]. Arch Med Res, 2009,40(4) :235 -240.
  • 8Shukla S, Gupta S. Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study [ J ]. Mol Carcinog, 2009,48 (3) : 243 - 52.
  • 9Moser C, Schachtschneider P, Lang SA, et al. Inhibition of insulin-like growth factor-1 receptor (IGF-IR) using NVP- AEW541 , a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis [ J ]. Eur J Cancer, 2008,44(11) :1577 -1586.
  • 10Sato A, Oya M, ho K, et al. survivin associates with cell proliferation in renal Cancer cells: regulation of survivin expression by insulin-like growth factor-1, interferon-gamma and a novel NF-kappaB inhibitor [ J ]. Int J Oncol, 2006, 28(4) :841 - 846.

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中国普通外科杂志
2009年 第6期

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