银杏达莫联合辛伐他汀治疗急性脑梗死的疗效观察

The curative effect observation of Yinxingdamo combined simvastatin in treatment with acute cerebral infarction

目的观察银杏达莫联合辛伐他汀治疗急性脑梗死的临床疗效。方法62例急性脑梗塞随机分为两组,治疗组34例,采用银杏达莫联合辛伐他汀治疗;对照组28例仅采用银杏达莫治疗,对比观察治疗前后两组的临床疗效、神经功能缺损程度及血脂水平的变化。结果治疗组的总有效率明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后两组神经功能缺损程度评分均较治疗前明显下降,差异有统计学意义(P<0.05),但两组比较差异无统计学意义(P>0.05)。治疗组治疗后TC、TG、LDL-C水平较治疗前明显下降,而HDL-C水平明显升高,差异均有统计学意义(P<0.05);并且治疗组治疗后TC、TG、LDL-C水平低于对照组治疗后水平,HDL-C高于对照组治疗后水平,差异均有统计学意义(P<0.05)。对照组治疗后TC、TG、LDL-C、HDL-C水平与治疗前比较,差异无统计学意义(P>0.05)。结论银杏达莫联合辛伐他汀治疗急性脑梗死效果明显,能有效改善神经功能,降低血脂水平。

OBJECTIVE To observe the clinical curative effect of Yinxingdamo combined simvastatin in treatment with acute cerebral infarction. METHODS 62 cases of acute cerebral infarction were randomly divided into two groups, treatment group with 34 cases was treated with Yinxingdamo combined simvastatin and control group with 28 cases was treated with Yinxingdamo only. The effective rate, neurologic impairment degree and blood fat level between the two groups were compared. RESULTS The effective rate in treatment group was significantly higher than that in control group（P 〈 0.05）. The neurologic impairment degree were significantly decreased after treatment in both groups（P 〈 0.05）, but there was no significant difference between the two groups（P 〉 0.05）. After treatment, the levels of TC, TG, LDL-C in treatment group were significantly decreased while the level of HDL-C was significantly increased（ P 〈 0.05）. Moreover, the levels of TC, TG, LDL-C in treatment group were significantly lower while the level of HDL-C was significantly higher than those in control group after treatment （P 〈 0.05）. There was no significant difference between pre-treatment and post-treatment in control group（P 〉 0.05）. CONCLUSION Yinxingdamo combined simvastatin in treatment with acute cerebral infarction is an effective method, which can improve the neurologic function and degrade the blood fat.