肾嫌色细胞癌的CT征象与MVD及Ki67表达的相关性研究

Correlative study between CT features and expression of MVD and Ki67 in renal chromophobe cell carcinoma

目的:探讨肾嫌色细胞癌(RCCC)中微血管密度(MVD)、Ki67抗原的表达与CT征象间的相关性。方法:对15例RCCC患者术前行SCT多期扫描检查,术后收集标本应用免疫组化PV9000法检测15例RCCC标本及5例正常肾组织中MVD和Ki67的表达,分析SCT表现与MVD和Ki67之间的关系。结果:RCCC中MVD、Ki67表达高于正常肾组织组;肿瘤边界与Ki67的表达呈正相关(P<0.05),与MVD的表达无统计学差异;RCCC肿瘤的大小、形态、最大强化程度、强化均匀性与MVD、Ki67的表达相关。结论:CT动态增强扫描可对RCCC进行较准确的术前诊断;RCCC的部分CT征象与MVD和Ki67的表达相关,提示这些征象可间接反映RCCC的生物学行为及预后。

Objective： To study the correlation between CT features and expression of MVD and Ki67 in renal chromo- phobe cell carcinoma （RCCC）. Methods： CT was performed preoperatively in 15 patients with RCCC by pathology. MVD and Ki67 expression were determined by immunohistochemica] PV9000 method in all patients. The correlation between expression of determined proteins and CT features in RCCC were studied. Results： The tumor boundary is correlated with increased ex- pression of Ki67, but not correlated with MVD. The positive expression of MVD and Ki67 in RCCC tissue is significantly higher than those of normal kidney tissue. The positive MVD and Ki67 were significantly correlated with the diameter of the tumor, the morphology of tumor, the degree aud the inhomogeneity of enhancement. Conclusion： The enhanced CT scan is re- liable for RCCC preoperative diagnosis. Part of CT signs is associated with the expression of MVD, Ki67. They can indirectly show the biological behaviour and malignant extent of RCCC.