环氧化酶2基因多态性与动脉粥样硬化缺血性脑卒中的相关性

Relationship between the COX-2 gene polymorphisms and atherothrombotic ischemic stroke

目的探讨中国汉族人环氧化酶2的单核苷酸多态性位点及单元型与动脉粥样硬化缺血性脑卒中的关系。方法对626名缺血性脑卒中患者和604名健康者检测环氧化酶2的两个多态位点:-1195G/A和8473T/C,并对每个基因位点和两个位点的单元型进行分析。结果8473T/C位点的基因型TC在疾病组中明显增多(经混杂因素校正后,OR=1.329,95%CI=1.028-1.719),单元型A-1195C8473的比率在疾病组较对照组高,Logistic回归分析显示带有单元型A-1195C8473的个体更容易患缺血性脑卒中(经混杂因素校正后,OR=1.372,95%CI=1.070-1.760)。结论在汉族人环氧化酶2的基因型TC(8473T/C位点)和单元型A-1195C8473可能是脑梗塞的遗传易感因素。

Objective To investigate whether single nueleotide polymorphisms （SNPs） and haplotypes of COX-2 gene were susceptible to atherothrombotic ischemic stroke in the Chinese Han population. Methods In this study two variants （ -1195G/A and 8473T/C） of COX-2 were examined among 626 patients with isehemic stroke and 604 control subjects. Polymorphisms were studied both individually and as haplotypes. Results The genotype TC in 8473T/C was significantly over-expressed in patients （OR = 1.329, 95% CI = 1.028 - 1.719, adjusted for confounding factors）. Further, the haplotype AC of - 1195G/A and 8473T/C was significantly higher in patients than that in the control subjects. Logistic regression analysis revealed that individuals having haplotype AC had an increased possibility of isehemic stroke （OR = 1.372, 95% CI = 1.070- 1.760, adjusted by confounding factors）. Conclusion The results suggest that genotype TC of COX-2 8473T/C and haplotype AC containing - 1195A and 8473C may be a crucial risk factor of genetic susceptibility to isehemic stroke in the Chinese Han population.