精神分裂症患者与过氧化氢酶（Catalase）基因多态性

The Association between Schizophrenics and Catalase Gene Polymorphism

目的：探讨过氧化氢酶（Catalase）基因多态性与精神分裂症的相关性。方法：采用Amp-RFLP（amplication-restriction freg-ment lengh polymorphis）方法对精神分裂症患者和对照组的过氧化氢酶基因相关性进行了研究。结果：167例精神分裂症患者与155例对照组之间过氧化氢酶基因型频率和等位基因频率无统计学意义,76例女性精神分裂症患者与60例对照组之间过氧化氢酶基因型频率（x^2=11.096,df=2,P=0.004）有显著性差异。结论：过氧化氢酶多态性与精神分裂症的遗传学并不存在关联性,但是研究表明过氧化氢酶基因型频率与女性精神分裂症患者有显著性差异。

Objective ：To explore the association between schizophrenics and catalase gene polymorphism. There is increasing evidence that free radial - mediated CNS neuronal dysfunction is involved in the pathophysiology of schizophrenia. This study was performed to examine the relationship between antioxidant defense system and schizophrenia by analyzing polymorphism of catalase gene, an antioxidant enzyme. Methods：Genotype and allele frequencies in the promoter region in the catalase gene using restriction fragment length polymorphism were studied, comparing 155 controls with 167 schizophrenics. Results： No difference was found between the schizophrenics and the controls in genotype and allele frequencies of Hinfl polymorphism in the catalase gene. Significant difference was found between the female schizophrenics and the female controls in the genotype distribution （ x^2 = 11. 096, df = 2, P = 0. 004 ）. Conclusions： The results do not support an association between polymorphism of eatalase gene and schizophrenia. However, this study suggests that Hinfl polymorphism in the catalase gene could be associated with female schizophrenics.