未服药与短期服药治疗的精神分裂症患者注意功能的对照研究

Attentional test between neuroleptic- naive and short- term medicated onset schizophrenic patients

目的：探讨未服药与短期服药治疗的发作期精神分裂症患者注意功能的特点。方法：采用倒行掩蔽测验（back-ward mask ingtest,BMT）和连续操作测验（continue performance test,CPT）分别对55名未服抗精神病药物、49名服药治疗不足1月的处于发作期、现病期在2年以内的精神分裂症患者和60名健康对照者的注意功能进行评估。结果：未用药组CPT1、CPT2、CPT3和CPT以及BMT1、BMT2、BMT3和BMT均显著低于对照组;用药组CPT1、CPT2、CPT3和CPT及BMT1、BMT3和BMT亦显著低于对照组,用药组BMT2与对照组之间的差异无显著性。用药与未用药组CPT和BMT各项得分之间无显著性差异。结论：急性发作期精神分裂症患者均存在注意功能缺陷,短期治疗可改善部分注意功能。

Objective：To explore the attentional function of neuroleptic - naive and short - term medicated onset schizophrenic patients. Methods：55 drug naive patients and 49 patients medicated for one month with schizophrenia and 60 normal controls were used backward masking test（BMT） and continue performance test （CPT）to study the attentional function. Results： Compared with the controls, neuroleptic - naive patients and medicated patients showed lower level in the number of CPT1, CPT2, CPT3 and CPT scores and BMT1, BMT3 and BMT scores. There is no significant difference in BMT2 between the short - term medicated patients and normal controls, There is no significant difference in CPT and BMT between the neuroleptic - naive patients and medicated patients. Conclusions： Onset patients with schizophrenia may have attentional dysfunction. Short - term medication may improve partial attentional function.