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信号传导蛋白Smad2和Smad3的研究进展 被引量：4

Research Advancement of Smad2 and Smad3 in Signal Conduction Albumen Smad
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摘要 Smad蛋自家族是近年来发现的新的细胞内信号转导蛋白,哺乳类中共发现了有8种不同的Smad蛋白,可分为3个不同的亚族:R-Smad、Co-Smad和I-Smad。Smad2和Smad3属于R-Smad,本文从Smad2和Smad3的结构、功能以及相关蛋白等多个方面探讨Smad2和Smad3在TGF-β1信号转导中的不同作用。 Smad protein family is a new kind of intracellular signal transduction protein, which has been found in recent years. Eight kinds of different Smad proteins have been found in mammals and were divided into three different sub - groups ： R - Smad, Co - Smad and I - Smad. Smad2 and Smad3 belong to R - Smad. The present paper explored different roles of Smad2 and Smad3 in TGF - β1 signal transduetian in many aspects such as structure, function and related protein.
作者 毕贤峰 姜双 张志纯
机构地区 辽宁医学院 中国医科大学
出处 《辽宁医学院学报》 CAS 2009年第3期273-275,共3页 Journal of Liaoning Medical University (LNMU) Bimonthly
关键词 SMAD SMAD2 SMAD3 转化生长因子Β1 Smad Smad2 Smad3 transforming growth factor- β1
分类号 R394.3 [医药卫生—医学遗传学]
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参考文献20

  • 1Mishra L,Sherry K,Tang Y,et al.The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer[J].Oncngene,2005,24 (37):5775-5789.
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二级参考文献8

  • 1Schnabl B, Kweon YO, Frederick JP, et al. The role of Smad 3 in mediating mouse hepatic stellate cell activation [J]. Hepatology, 2001,34:89-100.
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共引文献10

同被引文献43

引证文献4

二级引证文献9

辽宁医学院学报
2009年 第3期

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