5-氰基苯酞的合成

Synthesis of 5-chlorocarbonylphalide

抑郁症目前已成为一种普遍性的疾病,越来越受到关注和重视。在众多抗抑郁药物中,西酞普兰是最具竞争力的产品之一。5-氰基苯酞是合成西酞普兰的关键中间体。我们的合成路线是用对苯二甲酸合成5-苯酞甲酸,用5-苯酞甲酸制得5-苯酞甲酰氯,再氨化制得5-苯酞甲酰胺,最后脱水制得5-氰基苯酞;这是一种工艺简单,收率高,成本低廉的制备5-氰基苯酞的合成方法。

Depression has now become a universal disease. People pay more and more attention to it. In analgesics drugs, Citalopram is one of the current potential of the most competitive products. 5 - cyanophthalide is a key intermidiate of Citalopram. We introduced one 5 - cyanophthalide synthetic routes, by using benzenodicarbon acid synthesize 5 - carboxyphthallde, using 5 - carboxyphthalide synthesize 5 - chlorucarbonylphslide, using 5 - chlorucarbonylphslid synthesize 5 - carham- ylphthalid, and then for 5 - cyanophthalide. We have found a simple craft, high yields, the low cost of synthetic methods.