83例成人呼吸道感染病原分布及变迁分析

Pollution brush seized from the report of 83 cases of respiratory tract pathogen

目的监测成人呼吸道感染的病原分布特征和耐药情况,掌握其病原菌变迁规律,为成人呼吸道感染的治疗提供依据。方法采用纤支镜防污染毛刷获取成人呼吸道感染病原标本,送检标本先行草蓝染色,然后进行普通培养,以菌落数大于103cfu/mL为有效标本[1],依据培养的情况取优势菌落进行分纯、细菌鉴定和药敏测定。结果采用纤支镜防污染毛刷获取呼吸道感染病原标本83例,其病原分布显示:G+球菌和G-杆菌分别占全部分离菌株的30.12%和63.86%。结论G-菌属的感染逐渐增多,甚至超过G+菌属而居主导地位[2],G+球菌及G-杆菌对青霉素类的耐药性显著增加;G-杆菌对氨基甙类、喹诺酮类药物的敏感性较高,头孢类药物的抗菌活性与喹诺酮类相似。G+球菌对头孢菌素的敏感性高于青霉素类药物。

Objective To minitor adult respiratory tract infection pathogen distribution,drug resistance,the master of its patho- genic change,for the adult respiratory tract infection therapy. Methods The anti-pollution brush bronchoscopy to obtain specimens of adult respiratory tract infection pathogens, first orchid specimens submitted stain, and then proceed to the general culture to colo- nies〉10^3 cfu/ml for the effective specimen, based on taking advantage of the situation of culture for sub-colony of pure, bacterial identification and susceptibility determination. Results The use of bronchoscopy to obtain protected brush specimens of respiratory tract infection 83 cases of pathogen,and the pathogen distribution showed：G^＋ cocci and G-bacteria were separated from strains of the total 30. 12 percent and 63.86 percent. Conclusion G- species infection is gradually increasing,even more than G^＋ species live dominance, G^＋ cocci and G^- bacteria to penicillin-type drug resistance increased significantly; G^- bacilli has a higher drug sensi- tivity to aminoglycoside;and quinolone drug. cephalosporins and quinolones antibacterial activity is similar to G^＋ cocci on the sensi- tivity of cephalosporins than penicillin-type drugs.