摘要
合成了6个萘酰亚胺-多胺缀合物,化合物的结构经元素分析、1H NMR、13C NMR和MS确证。经MTT法对白血病细胞(K562)、人乳腺癌细胞(MB-231)和前列腺癌细胞(Ln cap cell)进行了体外活性测试,结果表明大多数化合物的体外抗肿瘤活性优于对照品氨萘非特(amonafide),其中化合物6d、6e和6f对正常人肝上皮细胞(QSG-7701)和肝癌细胞(BEL-7402)具有良好的选择性。
Six naphthalimide polyamine conjugates were synthesized and their structures were confirmed by elemental analysis, ^1H NMR, ^13C NMR and MS. Antitumor activities were evaluated in vitro using MTT assay on Leukemia cells （K562）, human breast cancer cells （MB-231） and prostate cancer cells （Ln cap cell）. The results showed that most of the six compounds were superior to the control （amonafide）, 6d, 6e, and 6f exhibited nice selectivity in a screen of hepatoma cells （BEL-7402） and human normal hepatocytes （QSG-7701）.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第7期754-757,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(20872027)
河南省科技攻关资助项目(082102270002)
关键词
萘酰亚胺
多胺缀合物
合成
抗癌活性
naphthalimide
polyamine conjugate
synthesis
antitumor activity
