玉竹中新的双氢高异黄酮

New homoisoflavanones from Polygonatum odoratum(Mill.) Druce

为了研究玉竹的化学成分,利用各种柱色谱及高压液相色谱等方法进行分离和纯化,根据理化性质和光谱数据鉴定化合物结构。从玉竹提取物中分离得到9个化合物,其中3个为新的双氢高异黄酮类化合物,分别为5,7-dihydroxy-6-methoxyl-8-methyl-3-(2′,4′-dihydroxybenzyl)chroman-4-one(1),5,7-dihydroxy-6-methyl-3-(2′,4′-dihydroxybenzyl)-chroman-4-one(2),5,7-dihydroxy-6-methoxyl-8-methyl-3-(4′-methoxybenzyl)chroman-4-one(3),其余化合物分别为disporopsin(4),柯伊利素(chrysoeriol,5),5,4′-dihydroxy-7-methoxy-6-methylflavane(6),N-trans-feruloyltyramine(7),N-trans-feruloyloctopamine(8),(+)-syringaresinol(9)。化合物1～3为未见文献报道的新化合物,化合物4～9为该植物中首次分离得到。

To study chemical constituents of Polygonatum odoratum （Mill.） Druce, the compounds were separated with column chromatography and HPLC. On the basis of physicochemical properties and spectral data, their structures were confirmed. Nine compounds were isolated and identified as 5,7-dihydroxy-6-methoxyl- 8-methyl-3-（2＇,4＇-dihydroxybenzyl）chroman-4-one （1）, 5,7-dihydroxy-6-methyl-3-（2＇,4＇-dihydroxybenzyl）chroman- 4-one （2）, 5,7-dihydroxy-6-methoxyl-8-methyl-3-（4＇-methoxybenzyl）chroman-4-one （3）, disporopsin （4）, chrysoeriol （5）, 5,4＇-dihydroxy-7-methoxy-6-methylflavane （6）, N-trans-feruloyltyramine （7）, N-trans-feruloylocto- pamine （8）, and （＋）-syringaresinol （9）. Compounds 1-3 are new homoisoflavanones. Compounds 4-9 are isolated from this plant for the first time.