摘要
考察葛根素油基微乳在大鼠小肠的吸收动力学特征和最佳吸收部位,研究微乳的吸收转运通路。大鼠在体肠回流实验考察小肠吸收行为,通过阻断和未阻断淋巴液及药物浓度的变化确定吸收转运通路。葛根素油基微乳在各肠段均有吸收,各肠段的Ka、Papp大小顺序是回肠>十二指肠>空肠>结肠,且回肠的Ka、Papp值显著大于其他肠段,不同浓度的药物吸收速率差异不显著(P>0.05)。经胃肠道生物转运的葛根素中约有36.8%经淋巴途径进入体循环,63.2%经非淋巴途径吸收。葛根素微乳在回肠吸收最好,属被动转运;转运通路是淋巴和非淋巴转运。
The best absorption location of puerarin microemulsion-in-oil in intestina parva of rat and pharmacokinetic characteristics, and the pathway of absorption and conveying of puerarin microemulsion were studied. In situ rat perfusion method was used to investigate the intestinal absorption of puerarin. Through the changes of drug concentration in blocked and unblocked lymphs, to determine the pathway of absorption and conveying. Puerarin microemulsion-in-oil can be absorbed in any part of intestine, and the Ka, Papp of every part is ileum 〉 duodenum 〉 jejunum 〉 colon, and the Ka, Papp of ileum is significantly larger than that of others. The absorption rate of different concentrations is not significantly different (P 〉 0.05). The puerarin transited by gastrointestinal tract, about 36.8% is absorbed by the lymphatic channels to enter the systemic circulation and 63.2% is absorbed by the non-lymphatic channels. The best part of intestine to absorb puerarin microemulsion is ileum, and it is passive transport. The pathway of conveying is lymphoid and non-lymphoid transit.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第7期798-802,共5页
Acta Pharmaceutica Sinica
基金
安徽省“十一.五”科技计划(08020303080)
关键词
葛根素
油基纳米乳
在体肠吸收
转运通路
puerarin
microemulsion-in-oil
intestinal absorption in situ
conveying pathway