环氧氯丙烷处理牛颈静脉带瓣管道生物学特性的研究

Biological characteristics of bovine jugular vein conduit fixed with epoxy chloropropan

目的评价环氧氯丙烷处理牛颈静脉带瓣管道(BJVC)的生物学特性。方法分别比较戊二醛处理、环氧氯丙烷处理、戊二醛+环氧氯丙烷联合处理和新鲜BJVC的管壁、瓣膜的厚度、大体形态、组织学特点、含水量、热皱缩温度及断裂强度,并进行可溶性蛋白含量的测定。结果戊二醛+环氧氯丙烷联合处理组BJVC的管壁、瓣膜厚度、组织含水量与未处理组相比较无明显变化;但管壁、瓣膜断裂强度和热皱缩温度均较新鲜对照组明显提高(P<0.05),可溶性蛋白的含量明显减少(P<0.05)。结论戊二醛+环氧氯丙烷联合处理的带瓣管道材料具有较好的生物学特性。

AIM： To evaluate the biological characteristics of bovine jugular vein conduit fixed with epoxy chloropropan. METHODS： Thickness, appearance, histology, water content, shrinkage temperature, breaking strength and soluble protein level of the wall and valve of bovine jugular vein conduit fixed, respectively, with glutaraldehyde, epoxy chloropropan, glutaraldehyde plus epoxy chloropropan were analyzed and compared with fresh ones. RESULTS： Thickness, appearance, histology, water content of wall and valve of bovine jugular vein conduit fixed with glutaraldehyde and epoxy chloropropan were similar to those of fresh ones. Although the shrinkage temperature and breaking strength were improved, soluble protein level markedly decreased. CONCLUSION： Bovine jugular vein conduit fixed with epoxy chloropropan shows good biological characteristics.