老年高血压病患者血尿酸水平及其他心血管相关因素

Analysis of serum uric acid and cardiovascular risk factors in elderly patients with essential hypertension

目的观察老年高血压病患者血尿酸,血脂,胰岛素抵抗指数和内生肌酐清除率等相关因素,探讨血尿酸在老年高血压病患者中的临床意义。方法老年高血压病组78例(A组),中青年高血压病组57例(B组),老年健康对照组41例(C组)。测量体质量指数(BMI),腰围(WC),腰臀比(WHR),检测血尿酸(SUA),总胆固醇(TC),三酰甘油(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),空腹血糖(FBG),空腹胰岛素水平(FIn),计算胰岛素抵抗指数(HOMA-IR),血肌酐(Scr),计算内生肌酐清除率(Ccr)。结果高尿酸血症发生率分别为A组:23%,B组:28%,C组:2%。A组与C组比较,A组BMI、WHR、SUA、TG、TC、SBP、DBP、FIn、HOMA-IR均明显升高,A组Ccr、HDL-C低于C组,具有统计学意义(P<0.05);A组与B组比较,A组WHR、FIn、HOMA-IR、Ccr、DBP低于B组,具有统计学意义(P<0.05)。结论高血压病患者高尿酸血症发生率明显升高,血尿酸可作为高血压病患者临床评估的重要指标之一。

AIM： To study serum uric acid （SUA）, blood lipids, insulin resistance, and endogenous creatinine clearance in elderly hypertensive patients. METHODS： Serum uric acid and other clinical data were collected in 78 elderly hypertensive patients （group A）, 57 middle-aged hypertensive patients （group B） and 41 elderly normal controls （group C）. RESULTS： Hyperuricemia in groups A, B and C was 23, 28 and 2%, respectively. In group A, the BMI, waist-to-hip ratio （WHR）, SUA, triglycerides, total cholesterol, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, Fin and HOMA-IR were higher than in group C, but creatinine clearance （Ccr） and high-density lipoprotein cholesterol were lower than in group C （P 〈 0. 05）. WHR, Fin, HOMA-IR, Ccr and DBP in group A were lower than in group B （P 〈 0.05）. CONCLUSION： The incidence of hyperuricemia is significantly increased in hypertensive patients. The serum uric acid is one of the important markers for clinical analysis in both elderly and middle-aged hypertensive patients.