2,2-二羟甲基丙酸的合成研究

Study on Preparation of 2,2Dimethylolpropanoic Acid

甲醛、丙醛为原料，经羟醛缩合，产物不分离直接氧化制备２，２-二羟甲基丙酸。羟醛缩合反应条件：甲醛与丙醛的摩尔比为２.２∶１，在碳酸钾催化下，２０～３０℃反应２４ｈ；氧化反应：双氧水与丙醛的摩尔比为０８∶１，４０～９０℃反应约１０ｈ。产品收率（按丙醛计）达６０％，纯度＞９９％。

The title compound was synthesized with the mixed aldol condensation and oxidation from formaldehyde and propaldehyde,without isolation of intermediate.Thus,a mixture of formaldehyde 2.2 mol,propaldehyde 1 mol and K 2CO 3 as catalyst at 20～30℃ was stirred for 24h,then added H 2O 2 0.8 mol and stirred at 40～90℃ for 10h to obtain 2,2dimethylolpropanoic acid.The yieid of the product was 60% and the purity was beyond 99%.