摘要
The effect of various concentrations of 2-hydroxypropyl-β-cyclodextrin （HP-β-CD） on the solubility of dihydroartemisinin （DHA） in aqueous solution at different pHs was investigated. The influence of different concentrations of 2-hydroxypropyl-β- eyclodextrin on the stability of dihydroartemisinin at 50, 60, 70 and 80 ℃ was also studied. Inclusion complex of dihydroartemisinin with 2-hydroxypropyl-β-cyclodextrin was prepared and characterized by X-ray diffraction and differential scanning calorimetry. The 2-hydroxypropyl-β-cyclodextrin effectively inhibited the hydrolysis of dihydroartemisinin and greatly increased its solubility. Furthermore, we showed that the higher concentrations of 2-hydroxypropyl-β-cyclodextrin, the better stability and solubility of dihydroartemisinin. When the temperature was increased, the stability of dihydroartemisinin decreased. Our results indicated that 2-hydroxypropyl-β-cyclodextrin can be used as a stabilizer and solubilizer of dihydroartemisinin.
各种不同浓度的2-羟丙基-β-环糊精对双氢青蒿素的不同pH值水溶液的溶解度的影响进行了研究。不同浓度的2-羟丙基-β-环糊精对双氢青蒿素在50,60,70,80oC条件下的稳定性也进行了研究。制备了双氢青蒿素2-羟丙基-β-环糊精包合物并通过X-射线衍射和差示热分析验证了包合物已经形成。2-羟丙基-β-环糊精有效地抑制了双氢青蒿素的水解,而且,2-羟丙基-β-环糊精的浓度越高,双氢青蒿素的溶解度和稳定性越好温度越高,双氢青蒿素的稳定性越差。2-羟丙基-β-环糊精是双氢青蒿素的增稳剂和增溶剂。
