42例头小畸形患儿早期认知发育分析

目的 探讨头围小于均值-2倍标准差的婴幼儿早期认知发育水平与相关因素的分析。方法42例头小畸形伴脑发育不良患儿，采用Gesell发育量表测定其认知发育水平，并就患儿性别、头围大小、初诊年龄、异常孕产史、头颅影像学检查等进行分析。结果42例患儿发育商值异常者占85．7％（36／42），影响早期认知功能的因素主要包括患儿有异常头颅影像学改变、性别、初诊年龄。结论通过分析发现85．7％的头小畸形伴脑发育不良患儿有不同程度的早期认知发育落后，且影响因素是多方面的；并且认为Gesell发育量表测试结合影像学检查可作为头小畸形患儿认知发育的早期筛查指标。

Objective To study the level of early cognition development and effects of cognition relevant factors on mierocephaly children. Methods Gesell developmental schedule test was measured in forty - two microcephaly cases with atelencephalia to analysis effects of cognition relevant factors including gender, HC, the age of primary doctors＇ office visiting, abnormal histories of pregnancy and birth, and abnormal head image examination on cognition development. Results The ration of abnormal developmental quotient in forty - two cases is 85.7 percent （36/42）. Abnormal head image examination, gender, and the age of primary doctors＇ office visiting are risk factors of cognition impairment in microcephaly with multi - element linear regression analysis. Conclusion There is a cognitive disorder in 85.7 percent of microcephaly children with atelencephalia that is influenced by multifarious factors. Gesell developmental schedules test combined with head imaging examination may be used as an early diagnosis method for screening cognition impairment in microcephaly children with atelencephalia,