2,3-二羟基哌嗪与几种氨基化合物的缩合反应研究

A Study on the Condensation Reaction of 2,3-bishydroxylpiperazine with Some Amino compounds

由乙二胺与乙二醛的缩合物２，３－二羟基哌嗪，分别与甲酰胺、脲和乙二胺反应，制得２，４，７，９，１１，１４－六氮杂三环［８，４，０，０３，８］十四烷六盐酸盐四水合物（１），２，５，７，９－四氮杂双环［４，３，０］壬－８－酮二盐酸盐－水合物（２）和２，５，７，１０－四氮杂双环［４，４，０］癸烷（３）。化合物１为未见文献报道的新化合物。化合物２的合成工艺条件优化后，反应得率与文献［１］相比有一定提高。化合物３的合成，由于将反应分为低温和高温两个缩合阶段，使反应得率提高到７７．５％。

Hydrochloride of 2,4,7,9,11,14 hexazatricyclo[8,4,0,0 3,8 ] tetradecane(1) and hydrochloride of 2,5,7,9 tetrazabicycls nonan 8 one(2) and 2,5,7,10 tetrazabicyclo decane(3) were synthesized via reaction of 2,3 bishydroxylpiperazine that is the condensation product of ethylenediamine and glyoxal with formamide,urea and ethylenediamine respectively.Compound 1 is a new compound that was not reported in literature.The yield of compound 2 is higher than that in literature (1) with the improvement of reaction condition.The yield of compound 3 is as high as 77.5%,because the condensation reaction of synthesising compound 3 is divided into low temperature and high temperature.