摘要
[Objective ] The study aimed to provide a theoretical basis for the clinical application of collagen peptide from Cyanea nozakii. [ Method] After acute toxicity test on mice, collagen peptide from C. nozakii were given to mice by continuous intragastric administration for 30 d at the doses of 25, 50, 100 mg/kg, and then the phagocytosis of macrophage, delayed type hypersensitivity (DTH) and serum hemolysin level were determined. [ Result] Collagen peptide from C. nozakii was atoxic or low toxic, and the three immune indices of experimental groups were signifi- canUy higher than those of the control group (treated with same volume of normal saline) at 0.05 or 0.01 level. E Conclusion] Collagen peptide from C. nozakii has a certain immunopotentiation.
1材料与方法1.1材料1.1.1霞水母胶原蛋白活性肽。由霞水母酶解提取、经冷冻干燥得到,为淡棕色粉末。由江南大学医药学院药物化学与药物分析实验室制备(具体方法参见已向国家申请的专利200710171188.6)。
基金
国家农业科技成果转化资金项目(2007GB2C100105)~~