Effects of Collagen Peptide from Cyanea nozakii on Mouse Immune Function

霞水母胶原蛋白活性肽对小鼠免疫功能的影响(英文)

[Objective ] The study aimed to provide a theoretical basis for the clinical application of collagen peptide from Cyanea nozakii. [ Method] After acute toxicity test on mice, collagen peptide from C. nozakii were given to mice by continuous intragastric administration for 30 d at the doses of 25, 50, 100 mg/kg, and then the phagocytosis of macrophage, delayed type hypersensitivity （DTH） and serum hemolysin level were determined. [ Result] Collagen peptide from C. nozakii was atoxic or low toxic, and the three immune indices of experimental groups were signifi- canUy higher than those of the control group （treated with same volume of normal saline） at 0.05 or 0.01 level. E Conclusion] Collagen peptide from C. nozakii has a certain immunopotentiation.

1材料与方法1．1材料1．1．1霞水母胶原蛋白活性肽。由霞水母酶解提取、经冷冻干燥得到，为淡棕色粉末。由江南大学医药学院药物化学与药物分析实验室制备（具体方法参见已向国家申请的专利200710171188．6）。