2,5-二甲基-4-羟基-3-己酮的合成

The Synthesis of 2,5Dimethyl4hydroxy3hexanone

以摩尔比为２∶１的金属钠和异丁酸甲酯为原料，用石油醚（６０～９０℃）作溶剂，在反应过程中加入与金属钠等摩尔的三甲基氯硅烷作为易发生副反应中间体的捕获剂，在室温下反应５ｈ合成了标题物。产率８９.４％，比文献［２］产率提高１４.４％。

The 2,5dimethyl4hydroxy3hexanone is prepared from 2mol sodium and 1mol methyl isobutyrate in petroleum ether (60～90℃)for 5h at room temperature.The Me 3SiCl useful as binder to catch reaction intermediate product of yielding side reaction is put in reaction mixture.The yield reaches 89.4% to be 14.4% up on that of literature .