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阿托伐他汀抗骨质疏松作用的研究 被引量:6

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摘要 目的探讨阿托伐他汀的抗骨质疏松作用。方法按照要求入选63例脑血管疾病病例,随机分为观察组和对照组。观察组在服用治疗脑血管疾病药物的同时服用阿托伐他汀10 mg,每晚1次,口服,服用1年。对照组单纯服用治疗脑血管疾病的药物。两组均在治疗前后进行血骨钙素、骨密度、血脂、肝功能、血常规的检查测定。结果与对照组比较,观察组在血脂降低的同时,血骨钙素和骨密度均有不同程度的提高,而且差异有显著性。结论阿托伐他汀具有抗骨质疏松的作用。
出处 《广东医学》 CAS CSCD 北大核心 2009年第7期1150-1151,共2页 Guangdong Medical Journal
基金 广东省佛山市科技攻关项目(编号:200608020)
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  • 1MUNDY G, GARRETT R, HARRIS S, et al. Stimulation of bone formation in vitro and in rodents by statins [ J]. Science, 1999, 286 (5 446 ) : 1 946 - 1 949.
  • 2BAUER D C, MUNDY G R, JAMAL S A, et al. Use of statins and fracture: results of 4 prospective studies and cumulative metaanalysis of observation studies and controlled trials [ J ]. Arch Intern Med, 2004, 164(2): 146-152.

同被引文献77

  • 1万玉仑,陈开勇.阿仑膦酸钠联合钙尔奇D治疗糖尿病伴骨质疏松症的疗效和安全性分析[J].医学信息(医学与计算机应用),2014,0(4):324-325. 被引量:2
  • 2刘茗露,王光辉,尹华,俞士水,唐肇波,王名晶.阿仑膦酸钠治疗老年骨质疏松的临床疗效[J].中国老年学杂志,2014,34(4):917-918. 被引量:18
  • 3Doggrell SA. Recent,important clinical trials of drugs in osteoporosis. Expert Opin Pharmaeother,2004,5 (7) : 1635-1638.
  • 4Russell RG. Bisphosphonates: mode of action and pharmacology. Pediatrics, 2007,119 ( Suppl 2 ) : S150-S162.
  • 5Rizzoli R. Longterm outcome of weekly bisphosphonates. Clin Orthop Relat Res,2006,443 (2) :61-65.
  • 6Saag K, Lindsay R, Kriegman A, et al. A single zoledronic acid Infusion reduced bone resorp tionmarkersmore rap idly than weekly oral alendronate in postmenopausal women with low bone mineral density. Bone ,2007,40 (5) : 1238-1243.
  • 7Ohnaka K, Shimoda S, Nawata H, et al. Pitavastatin enhanced BMP- 2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun, 2001,287 (2) :337-342.
  • 8Kaji H,Kanatani M, Sugimoto T, et al. Statins modulate the levels of osteoprotegerin/receptor activator of NF-kappa B ligand mRNA in mouse bone-cell cultures. Horm Metab Res, 2005,37 ( 10 ) : 589-592.
  • 9Charbonneau F,Anderson TJ,Title L,et al.Modulation of arterialreactivity using amlodipine and atorvastatin measured by ultrasoundexamination(MARGAUX)[J].Atherosclerosis,2008,197(1):420-427.
  • 10Corsini A.Fluvastatin:effects beyond cholesterol lowering[J].JCardiovasc Pharmacol Ther,2000,5(3):161-175.

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