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干扰素α1b治疗HBeAg阳性慢性乙型肝炎的临床疗效 被引量:2

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摘要 目的探讨干扰素(IFN)α1b对HBeAg阳性慢性乙肝患者的临床疗效。方法将108例HBeAg阳性慢乙肝患者随机分为观察组52例和对照组56例。对照组给予常规治疗,观察组在此基础上给予IFNα1b联合治疗,疗程均为6个月。比较两组在治疗结束后肝功能、乙肝病毒血清学指标和不良反应的差异。结果观察组在肝功能改善和乙肝病毒血清学指标均优于对照组。不良反应观察组大于对照组,但患者均能耐受。结论IFNα1b在治疗HBeAg阳性慢性乙肝方面,对肝功能和乙肝病毒血清学指标方面具有肯定的疗效,不良反应轻,值得临床推广。
出处 《广东医学》 CAS CSCD 北大核心 2009年第7期1161-1162,共2页 Guangdong Medical Journal
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  • 1刘金霞,陆宪忠.α-1b干扰素联合迈普新治疗慢性乙型肝炎效果观察[J].山东医药,2005,45(8):14-14. 被引量:2
  • 2Lindahl P,,Leary P,Gresser I.Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes[].Proceedings of the National Academy of Sciences of the United States of America.1972
  • 3Lindahl P,Gresser I,Leary P,et al.Interferon treatment of mice:enhanced expression of histocompatibility antigens on lymphoid cells[].Proceedings of the National Academy of Sciences of the United States of America.1976
  • 4Casanova JL,Abel L.The human model:a genetic dissection of immunity to infection in natural conditions[].Nature Reviews Immunology.2004
  • 5Chelbi-Alix MK,Wietzerbin J.Interferon,a growing cytokine family:50years of interferon research[].Biochimie.2007
  • 6Marcellin P,Piratvisuth T,Brunetto M,et al.Virological and biochemical response in patients with HBeAg-negative chronic hepatitis B treated with PEGASYSwith or without lamivudine:results of4-year follow-up:11%HBsAg clearance[].therd annual meeting of the European association for the study of the liver.2008
  • 7Fried MW,Piratvisuth T,Lau GK,et al.HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B[].Hepatology.2008
  • 8Piccolo P,Lenci I,Di Paolo D,et al.Peginterferon alpha-2a plus adefovir vs peginterferon alpha-2a for48weeks in HBeAg negative chronic hepatitis B:preliminary24week results of the PEG FOR B randomized multicenter trial[].Program and abstracts of thend annual meeting of the European association for the study of the liver.2007
  • 9Alter HJ.HCV natural history:the retrospective and prospective in perspective[].Journal of Hepatology.2005
  • 10McHutchison JG,,Gordon SC,Schiff ER,et al.Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C.Hepatitis Interventional Therapy Group[].The New England Journal of Medicine.1998

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