摘要
恶性肿瘤的侵袭和转移是恶性肿瘤治疗失败的主要因素,也是恶性肿瘤治愈率低的主要原因。恶性肿瘤转移的确切机制目前尚不清楚,该机制涉及了肿瘤自身与宿主之间错综复杂的关系,以及多种基因的调控。Sipa1基因是近年来发现的肿瘤转移候选基因,研究证明Sipa1基因结构及功能异常与肿瘤的发生发展有十分密切的关联。本文就Sipa1基因在恶性肿瘤侵袭转移中的作用作一综述。
The invasion and metastasis of malignant tumors are major factors in treatment failure and the low cure rate. The exact mechanism of malignant tumor metastasis is unclear at present. Which involved in the tumor itself and the intuicate relationship with the host, as well as the regulation of vailous genes. In recent years, Sipa1 gene are found as a candidate gene in malignant tumor metastasis,studies have proved sipal abnomal stracture and function has significant correlation in tumor occurrence and development. This paper review the role of Sipa1 gene in malignant tumor invasion and metastasis.
出处
《内蒙古医学院学报》
2009年第3期239-243,共5页
Acta Academiae Medicinae Neimongol
基金
内蒙古自治区自然科学基金(200711020916)
