凯时(前列腺素E_1注射液)治疗椎基底动脉供血不足患者42例临床分析

The Clinical Analysis of the Prostaglandin EI in Treating 42 Patients with Vertebrobasilar Insufficiency

目的:探讨凯时注射液治疗椎基地动脉供血不足的临床机制和治疗效果。方法:椎基地动脉供血不足患者82例随机分为两组,治疗组42例,对照组40例。治疗组给予凯时10μg加入0.9%生理盐水100ml静滴,1次/日,连续应用14天,对照组给予注射用盐酸川荨嗪0.12g加入0.9%生理盐水250ml静滴,1次/日,14天为一疗程。治疗期间两组均不使用其它扩血管药物。对临床疗效及学业流变学指标进行统计分析。结果:治疗组总有效率95.2%,对照组总有效率77.5%,治疗组实验室、血流变学指标改善优于对照组。结论:凯时注射液治疗椎基地动脉供血不足疗效显著,在临床上值得推广。

Objective ：To explore the clinical mechanism and effect of the Prostaglandin El in treating 42 patients with vertebrobasilar insufficiency. Methods： 82 cases with vertebrobasilar insufficiency were randomly divided into two groups（42 cases in the treatment group and 40 cased in the control group）. Patients in the treatment group were injected with the prostaglandin EI 10ug, and the patients in the control group were injected with Chuanxiongqin injection 120mg. All drug were add in the Normal Saline（250ml）. The therapy lasted 14 days. All data were analyzed statistiealy. Results ： The total effective rate was 95, 2% in the treatment group, and that in the control group was 77.5%. There is significantly difference in the two groups （ P 〈 0.05 ）. Conclusion ： There is distinct clinical effect of prostaglandin EI in treating patients with vertebrobasilar insufficiency. It could be used widely.