轻度认知障碍患者血浆蛋白磷酸酯酶-2A的活性变化

The Alteration of Protein Phosphotase-2A Activities in Plasma of Mild Cognitive Impairment

目的:探讨轻度认知功能障碍(Mild Cognitive Impairmem,MCI)患者血浆蛋白磷酸酯酶-2A(protein phosphotaae-2A,PP-2A)的活性变化。方法:用放射性配体结合实验检测不同病程MCI患者及正常老年人对照组血浆PP-2A的活性变化。结果:1年MCI组(0.94±0.09)PP-2A的活性与对照组(1.01±0.08)比较无明显降低(P>0.05),而2年MCI组(0.89±0.07)及3年MCI组(0.86±0.10)血浆PP-2A活性与对照组相比明显降低(P<0.05,P<0.01),与1年MCI组的PP-2A的活性比较无明显差别(P>0.05)。结论:病程延长的MCI患者血浆PP-2A的活性降低,对MCI的诊断可能有潜在的价值。

Objective ： Our purpose was to explore the alteration of protein phosphotase-2A （PP-2A） activities in plasma of the patients with mild cognitive impairment. Methods：the activities of PP-2A was measured by by 32P liquid scintillography for incorporated radioactivity in control group,1-year MCI group ,2-year MCI group and 3-year MCI group. Results L the activities of PP-2A in 1-year MCI group（0. 94 ±0. 09） and was not obviously lower as compared with control group （ 1.01 ± 0. 08） （ P 〉 0, 05 ）, bat a difference was induced in 2-year MCI group （0. 89 ± 0. 07 ） and 3-year MCI group （0. 86 ± 0. 10 ） as compared with control group（ P 〈 0. 05, P 〈 0, 01 ）. There was not an obvious difference among these three MCI groups （ P 〉 0.05 ）. Conclusions ：Lower activities of PP-2A in plasma imply a possible value of MCI diagnosis.