急性冠脉综合征合并糖代谢异常患者的血脂与凝血-纤溶活性的异常

Blood Lipid and Plasminogen Activity on Abnormal in the Patients with Acute Coronary Syndrome Accomplied by Abnormal Glucose Regulation

目的:通过测定纤溶酶原激活物抑制剂-1(PAI-1)及纤维蛋白原(Fbg),探讨急性冠脉综合征合并糖代谢异常患者的凝血及纤溶系统功能异常。方法:把急性冠脉综征患者分为糖耐量正常组(A组)和糖代谢异常组(B组),测PAI-1、Fbg含量及高敏C反应蛋白(hs-CRP)、血脂、胰岛素水平。结果:急性冠脉综征合并糖代谢异常患者较正常对照组PAI-1、Fbg、hs-CRP增高(P<0.01).总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)增高,高密度脂蛋白胆固醇(HDL-C)降低(P<0.05)。较急性冠脉综征不合并糖代谢异常患者PAI-1、Fbg、hs-CRP增高。结论:急性冠脉综征合并糖代谢异常患者存在较低的纤溶活性。

Objective：Serum plasminogen activator inhibitor-1 （PAI-1） and fibrinogen（Fbg） levels were measured to evaluate the abnormal plasminogen activity in patients with acute coronary syndrome（ACS） accomplied by abnormal glucose regulation. Methods： Patients with ACS were divided into two groups. The normal glucose regulation （A Group）. The abnormal glucose regulation （ B Group）. The heahy contronls （C Group ）. To measure PAI-1 .Fhg. high sensitivity C reactive protein（hs-CRP） ,blood lipid and insulin. Results： PAI-1 , Fbg and hs-CRP levels in A Group were notably higher than those in C Group （ P 〈 0. 01 ）. TC,LDL-C. TG were higher, HDL-C were lower （ P 〈 0. 05 ）. PAI-1 .Fbg and hs-CRP levels in A Group were higher than those in B Group. Conclusions：The lower plasminogen activity in the patients with ACS accomplied by abnormal glucose regulation.