盐酸左旋布比卡因复合枸橼酸舒芬太尼、咪唑安定用于剖宫产术后硬膜外自控镇痛的效果

Effect of Levobupivacaine Combined with Sufentanil and Midazolam in Patient-controlled Epidural Analgesia after Cesarean Section

目的:评价S-(-)-1-丁基-N-(2,6-二甲基苯基)-2-哌啶甲酰胺盐酸盐(盐酸左旋布比卡因)复合N-[4-(甲氧甲基)-1-[2-(2-噻吩基)乙基]-4-哌啶基]-N-苯丙酰胺(枸橼酸舒芬太尼)、8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5-a][1,4]苯并二氮杂芭卓(咪唑安定)用于剖宫产术后硬膜外自控镇痛(PCEA)的效果。方法:60例剖宫产者根据术后自控镇痛配药不同随机分为A组(体积分数0.125%的盐酸左旋布比卡因(125 mg)+枸橼酸舒芬太尼0.4μg/mL),B组(0.125%的盐酸左旋布比卡因(125 mg)+枸橼酸舒芬太尼0.6μg/mL)和C组(0.125%盐酸左旋布比卡因(125 mg)+枸橼酸舒芬太尼0.4μg/mL+咪唑安定2 mg);观察术后疼痛视觉模拟评分、Ramsay镇静评分、改良Bromage分级及不良反应。结果:B、C组镇痛效果相当,但B组不良反应发生率高于C组(P<0.05)。结论:盐酸左旋布比卡因复合枸橼酸舒芬太尼、咪唑安定用于剖宫产术后PCEA效果确切。

Objective： To evaluate the effects of levobupivacaine combined with sufentanil and midazolam in patientcontrolled epidural analgesia after cesarean section. Methods： Sixty cases with cesarean section according to postoperative prescription-controlled analgesia were randomly divided into group A（0.125 % levobupivacaine（ 125 mg）＋sufentanil 0.4 μg/mL）, tVoup B（0.125% levobupivacaine（125 mg）＋sufentanil 0.6 μg/mL）, group C（0.125% levobupivacaine（125 mg）＋sufentanil 0.4 μg/mL＋midazolam 2 mg）. The postoperative visual analogue scale, Ramsay sedation score, modified Bromage grade and adverse reactions were observed. Results： The analgesic effects in group B and C were considerable, but the incidence rates of adverse reactions in group C were lower than those in group B. Conclusion： The effect of levobupivacaine combined with sufentanil and midazolam in patient-controlled epidural analgesia after cesarean section is good.