胃癌患者血清肝细胞生长因子的检测及意义

Clinical significance of serum hepatocyte growth factor detection in gastric cancer patients

目的探讨血清肝细胞生长因子（HGF）在胃癌患者血清水平变化的临床意义。方法选取手术和临床病理证实为胃癌的60例患者，采用酶联免疫吸附法（ELISA）检测其血清HGF水平，其中40例行胃癌根治术，20例患者因已有远处转移而丧失根治手术机会。分别检测胃癌患者术前、术后7d和3个月者血清HGF的水平；同时选取加例慢性胃炎患者以及40例门诊健康体检者作为对照。结果胃癌患者血清HGF水平明显高于慢性胃炎组和正常对照者（P〈0．01）。肿瘤血管侵犯者血清HGF明显升高（P〈0．05）；有淋巴结转移者，血清HGF水平明显高于无淋巴结转移者（P〈0．05）；肝脏转移者血清HGF水平明显高于无肝脏转移者（P〈0．05）；肿瘤最大直径t〉3cm的胃癌患者血清HGF水平明显高于最大直径〈3cm的胃癌患者（P〈0．05）；按胃癌TNM分期标准，Ⅰ期和Ⅱ期患者血清HGF水平明显低于Ⅲ期和Ⅳ期患者（P〈0．05）；胃癌患者血清HGF水平与性别、年龄及组织学类型无明显关系（P〉0．05）。40例手术治疗患者术后1周血清HGF水平明显降低，术后3个月降低更为明显（P〈0．05和P〈0．001）。结论HGF在胃癌的发生发展过程中可能起重要作用，血清HGF水平的检测可成为胃癌病情程度监测和预后判断的重要指标。

Objective To explore the clinical significance of serum HGF level changes in gastric cancer pafients. Methods 60 cases of patients who operatied and clinicopathulogical confirmed gastric cancer,were detected serum HGF level by enzyme linked immunosorbent assay（ELISA）. 40 cases were administered radical gastrectomy ,20 cases of patients who had distant metastasis and loss operative chance were detected 7 days and 3 months preoperafive, postoperative seram HGF level respectively. At the same time 40 cases of chronic gastritis patients and 40 cases of healthy examination people were selected as control group. Results Serum HGF level in patients with gastric cancer was significantly higher than that of chronic gastritis and normal controls（ P 〈0. 01 ）. The serum HGF level of patients with tumor vascular invasion significantly increased（ P 〈 0. 05）. The patients with lymph node metastasis, serum HGF level was significantly higher than that patients with no lymph node metastasis（P 〈0. 05）. The senlm HGF level of patients with liver metastasis was significantly higher than that patients with no liver metastasis（P 〈 0. 05 ）. The se- nun HGF level of gastric cancer patients whose maximum diameter of the tumor ≥3cm were significantly higher than that maximum diameter of the tumor 〈 3cm （ P 〈 0. 05）. According to TNM staging of gastric cancer, the serum HGF level of Ⅰ phase and Ⅱ phase patients were significantly lower than that Ⅲ phase and Ⅳ phase patients（P 〈0. 05）. The serum HGF level of gastric cancer patients had no significant correlation with sex,age and histological type（ P 〈 0. 05）. The serum HGF level of 40 cases of patients who were 1 week after surgery were significantly decreased, the patients who were 3 months after surgery were more obvious（P 〈0. 05 and P 〈0. 001 ）. Conclusion HGF may play an important role in gastric cancer occurrence and development. The detection of serum HGF level can become an impertant index for monitoring the degree of gastric cancer and prognosis of patients.