摘要
目的观察比较中介素在低氧性肺动脉高压大鼠血浆和支气管肺泡灌洗液含量的变化。方法雄性Wistar大鼠被随机分为4组，对照组、低氧1周组、2周组、3周组。利用放免分析法测定大鼠血浆和支气管肺泡灌洗液的含量。结果低氧组大鼠血浆和支气管肺泡灌洗液中介素含量明显高于对照组。同时支气管肺泡灌洗液和血浆的变化趋势一致。结论中介素血浆和支气管肺泡灌洗液含量增高，提示机体可能对缺氧性肺动脉高压起到一定的缓冲和保护作用。
Objective To observe and compare the changes of Intermedin＇s contents in plasma and bronchoalveelar lavage fluid （BALF） in rats with hypoxic pulmonary hypertension. Methods male Wistar rats were randomly divided into control group and 1,2 and 3 weeks hypoxia group. Intermedin＇s contents in plasma and bronchoalveolar lavage fluid were measured by radioimmunoassay. Results Intermedin＇s contents in plasma and bronchoalveolar lavage fluid were markedly increaseded compared with control group. Meanwhile transformational trend is consistent between plasma and bronchoalveolar lavage. Conclusions Intermedin＇s contents in plasma and bronchoalveolar lavage increase, which shows that there is protection and moderation to hypoxic pulmonary hypertension.
出处
《中国基层医药》
CAS
2009年第6期1015-1016,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
中介素
低氧
肺动脉高压
Intermedin
hypoxia
pulmonary hypertension
