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自噬参与帕金森病发病的研究进展 被引量：3

Progress in role of autophagy in pathogenesis of Parkinson＇s disease
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摘要 近年来，蛋白质的降解障碍被认为是帕金森病（Parkinson’Sdisease，PD）发病过程中的重要因素，人们已经公认泛素一蛋白酶体系统（ubiquitin--pro—teasomesystem，UPS）功能异常或衰竭能够导致细胞内异常蛋白蓄积、细胞功能障碍，甚至细胞凋亡。与此同时，蛋白降解的另一条途径——自噬-溶酶体途径（autophagy—lysosomepathway，ALP）也已成为了生命科学领域的研究热点，自噬与神经变性疾病，尤其是PD的关系日益受到人们的重视。
作者 张磊 徐晓恒 周丹
机构地区 吉林大学第二医院儿科
出处 《神经疾病与精神卫生》 2009年第3期260-263,共4页 Journal of Neuroscience and Mental Health
关键词 自噬 帕金森病 治疗 Autophagy Parkinson＇s disease Treatment
分类号 R742.5 [医药卫生—神经病学与精神病学] R576 [医药卫生—消化系统]
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参考文献30

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共引文献1

同被引文献42

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引证文献3

二级引证文献1

神经疾病与精神卫生
2009年 第3期

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