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肠道上皮细胞特异转录因子CDX2研究进展 被引量:4

Research Progress on Intestinal Epithelial Specific Transcription Factor CDX2
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摘要 CDX2是一种新发现的肠道上皮细胞特异性核转录因子,在调节肠道基因表达与肠道发育及对肠道上皮细胞分化、增殖方面具有重要调节作用。笔者就有关CDX2的研究进展作一综述。 CDX2 is a recently found nuclear transcription factor, which is specifically expressed in intestinal cells. CDX2 is involved in the regulation of intestine specific genes, it plays a significant role in the differentiation, proliferation in the intestihal epithelium cells. This article reviews the previous studies of CDX2.
出处 《中国畜牧兽医》 CAS 北大核心 2009年第6期65-69,共5页 China Animal Husbandry & Veterinary Medicine
基金 国家自然科学基金(30671519) 国家自然科学基金委-广东省人民政府联合基金(U0731004)
关键词 肠道上皮 转录因子 CDX2 尾型相关同源盒基因 intestine epithelia transcription factors CDX2 caudal-related homeobox gene
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  • 1高正义,王志祥,陈道付,吕久菊.谷氨酰胺的生理功能及其在幼龄动物营养中的应用[J].中国畜牧兽医,2007,34(8):16-19. 被引量:6
  • 2Bai Y Q, Yamamoto H, Yoshimitsu A, et al. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach[J].Cancer Letters,2002,176(1) :47-55.
  • 3Beck F,Chawengsaksophak K,Jenni L, et al. A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice[J].Developmental Biology,2003,255(2) :399-406.
  • 4Beck F, Erler T, Russell A, et al. Expression of Cdx-2 in the mouse embryo and placenta: Possible role in patterning of the extra-embryonic membranes [J]. Developmental Dynamics, 1995, 204(3) :219-227.
  • 5Boudreau F, Rings E H ,Wering H M V, et al. Hepatoeyte-nuclear-factor-lalpha(HNF-lalpha), GATA-4 and caudal-related homeodomain protein Cdx2 functionally interact to modulate intestinal gene transcription:Implication for the developmental regulation of the sucrase-isomaltase gene [J ]. Journal of Biological Chemistry, 2002,31909- 31917.
  • 6Boulanger J, Vezina A, Mongrain S, et al. C.dk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells[J]. Journal Bioogical Chemistry,2005,280(18):18095-18107.
  • 7Cathy M,Jesper T T,Spodsberg N,et al. Interaction between the homeodomain proteins Cdx2 and HNFla mediates expression of the lactase-phlorizin hydrolase gene[J]. Journal of Biochemical, 2000,346: 529-535.
  • 8Di Guglielmo M D, Park J, Stephanie S, et al. Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C[J]. FEBS Letters,2001,507(2) :128-132.
  • 9Domon-Dell C,Wang Q,Kim S, et al. Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells[J]. Gut,2002,50(4) :525-529.
  • 10Drummond F J,Sowden J, Morrison K, et al. Colon carbonic anhydrase 1: transactivation of gene expression by the homeodomain protein Cdx2 [J]. FEBS Letters, 1998,423 (2) : 218 -222.

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