1Goldstein AL,Low T,McAdoo M,et al..Thymosin alpha 1:isolation and sequence analysis of an immunologically active thymic polypeptide[J].Proc Natl Acad Sci USA,1977,74:725.
2Grottesi A,SeRe M,Palamara T,et al..The conformation of peptide Tα1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy.A possible model for its interaction with the lymphocyte membrane[J].Peptides,1998,19(10):1731.
4Oates K,Erdos M.Biochemical identification of thymosin alpha-1:its phylogenetic distribution and evolutionary implications[J].Comp Biochem Phys,1989,94-B(4):759.
5Rost K,Wierich W,Masayuki F,et al..Pharmacokinetics of thymosin alpha 1 after subcutaneous injection of three different formulations in healthy volunteers[J].Int J Clin Pharmacol Ther,1999,37:51.
6Schulof RS,Lloyd M,Cox J.An evaluation of two different schedules of synthetic thymosin alpha 1 administration in patients with lung cancer:preliminary results.In:Goldstein A,ed.Thymic Hormones and Lymphokines[M].New York:Plenum Press,1984.601.
7Ancel CD,Phipps J,Young L.Thymosin alphal[J].Am J Health Syst Pharm,2001,58(10):879.
8Knutsen AP,Freeman JJ,Mueller KR,et al..Thymosin-alphal stimulates maturation of CD 34+ stem cells into CD 3+ 4+ cells in an in vitro thymic epithelia organ coculture model[J].Int J Immunopharmacol,1999,21(1):15.
9Silecchia G,Guarino E,Sinibaldi V,et al..Efficacy of repeated cycles of chemoimmunotherapy with thymosin alpha 1 and interleukin-2 after intraperitoneal 5-fluorouracil delivery[J].Cancer Immunol Immunother,1999,48(4):172.
10Suda T,Zlotnik A.IL-7 maintains the T cell precursor potential of CD 3-CD 4-CD 8-thymocytes[J].J Immunnol,1991,146:3068.
4Chang Yichen,Li Min,Yang Hni,et al.Roles of thymosins in cancers and other organ systems[J].World J Surg,2005,29(3):264-270.
5Spangelo B L,Pompilius M,Farrimond D D,et al.Presence ofa peptide component of thymosin fraction-5 manifesting discrete cytostatic properties in HL-60 human promyelocytic leukemia cells[J].Int Immunopharm,2005,5(7-8):1317-1329.
6John W,Hadden,M D.Aspects of the immunopharmacology of thymosin[J].Clin Appl Immunology Rev,2001,(1):187-191.
7Sarandeses C S,Covelo G,Diaz-Jullien,et al.Prothymosin alpha is processed to thymosin alpha 1 and thymosin alpha 11 by a lysosomal asparaginyl endopeptidase[J].J Biol Chem,2003,278 (15):13286-13293.
8Grottesi A,Sette M,Palamara T,et al.The conformation of peptide T α 1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy.A possible model for its interaction with the lymphocyte membrane[J].Peptides,1998,19(10):1731-1738.
9Romani L,Bistoni F,Gaziano R,et al.Tα1 activates dendritic cells for anifungal Thl resistance through toll-like receptor signaling[J].Blood,2004,103 (11):4232-4239.
10Naz R K,Kaplan P,Badamchian M,et al.Effects of synthetic T α l and its analogs on fertilizability of human sperm:search for a biologically active,stable epitope[J].Arch Androl,1995,5 (1):63-69.
8Pierluigi B, D' Angelo C, Fallarino F, et al. Thymosin alphal : the regulator of regulators? [J]. Ann N Y Acad Sci, 2010, 1194:1 -5.
9Garaci E, Pica F, Rasi G, et al. Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application[ J]. Int J Immunopharmacol, 2000, 22(12) : 1067 - 1076.
