多巴胺D2受体基因TaqIB多态性与酒依赖的关系

Association of DRD2 Receptor Gene TaqIB Polymorphism with Alcohol Dependence

目的:探讨汉族人群中多巴胺D2受体(DRD2)基因TaqIB多态性与酒依赖的相关性。方法:采用聚合酶链式反应一限制性片断长度多态性(PCR-RFLP)技术,检测酒依赖组(80例)和对照组(95例)的DRD2基因TaqIB多态性的基因型和等位基因频率。结果:酒依赖组和对照组的DRD2基因TaqIB多态性的基因型和等位基因频率有显著性差异,等位基因B2的携带者显著降低其嗜酒的发生率(OR:1.636,P<0.05)。结论:本研究提示,在汉族人群中DRD2基因TaqIB多态性与酒依赖存在相关性,TaqIB2等位基因可能是降低酒依赖发病的影响因子。

Objective： To investigate the association of DRD2 receptor gene TaqlB polymorphism with alcohol dependence in the Han Chinese. Methods： Genotype and allele frequencies of TaqlB polymorphism of DRD2 receptor gene in 80 alcohol dependence pa- tients （dependence group） and 95 normal controls （control group） were examined by polymemse chain reaction and restriction fragment length polymorphism （PCR-RFLP） technique. Results： The genotype and allele frequencies of DRD2 gene TaqlB polymorphism differed significantly between dependence group and control group. B2 allele frequency was associated positively with alcohol dependence （OR： 1.636,P〈0.05）. Conclusion： DRD2 receptor gene TaqlB polymorphism has an association with alcohol dependence of patients, suggest- ing that it may be a factor responsible for decreasing susceptibility for alcohol dependence in the Han Chinese.